Design, synthesis, and biological evaluation of potent thiosemicarbazone based cathepsin L inhibitors
نویسندگان
چکیده
منابع مشابه
Design, synthesis, and evaluation of inhibitors of cathepsin L: Exploiting a unique thiocarbazate chemotype.
Recently, we identified a thiocarbazate that exhibits potent inhibitory activity against human cathepsin L. Since this structure represents a novel chemotype with potential for activity against the entire cysteine protease family, we designed, synthesized, and assayed a series of analogs to probe the mechanism of action, as well as the structural requirements for cathepsin L activity. Molecular...
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ژورنال
عنوان ژورنال: Bioorganic & Medicinal Chemistry Letters
سال: 2010
ISSN: 0960-894X
DOI: 10.1016/j.bmcl.2009.12.090